Question: Which is mismatched?

A) Fleming - penicillin

B) Domagk - sulfonamide

C) Ehrlich - tetracycline

D) Florey and Chain - penicillin

E) none of the choices are correct

Answer: Ehrlich - tetracycline

Question: Salvarsan was

A) discovered in the mid-1900’s

B) used to treat syphillis

C) formulated from the red dye prontosil

D) first discovered as a product of Penicillium notatum

E) discovered by Robert Koch

Answer: used to treat syphilis.

Question: Substances that are naturally produced by certain microorganisms that can inhibit or destroy other microorganisms are called

A) antibiotics

B) narrow-spectrum drugs

C) semisynthetic drugs

D) synthetic drugs

E) broad-spectrum drugs

Answer: antibiotics.

Question: Antimicrobics effective against a wide variety of microbial types are termed

A) antibiotics

B) narrow-spectrum drugs

C) semisynthetic drugs

D) synthetic drugs

E) broad-spectrum drugs

Answer: broad-spectrum drugs.

Question: Antibiotics are derived from all the following except

A) Penicillium

B) Bacillus

C) Staphylococcus

D) Streptomyces

E) Cephalosporium

Answer: Staphylococcus.

Question: Important characteristics of antimicrobic drugs include

A) low toxicity for human tissues

B) high toxicity against microbial cells

C) do not cause serious side effects in humans

D) stable and soluble in body tissues and fluids

E) all of the choices are correct

Answer: All of the choices are correct

Question: Broad-spectrum drugs that disrupt the body’s normal flora often cause

A) nephrotoxicity

B) superinfections

C) allergic reactions

D) drug toxicity

E) all of the choices are correct

Answer: superinfections.

Question: Penicillins and cephalosporins

1. are metabolic analogs of PABA and block folic acid synthesis.

2. b. attach to the 30S ribosomal subunit and disrupt protein synthesis.

3. c. damage cell membranes.

4. d. block the peptidases that cross-link glycan molecules.

5. Answer: block the peptidases that cross-link glycan molecules.

6. Question: Sulfonamides

7. A) interfere with elongation of peptidoglycan

8. B) are metabolic analogs of PABA and block folic acid synthesis

9. C) attach to the 30S ribosomal subunit and disrupt protein synthesis

10. D) damage cell membranes

11. E) block peptidases that cross-link glycan molecules

12. Answer: are metabolic analogs of PABA and block folic acid synthesis

13. Question: Aminoglycosides

14. A) interfere with elongation of peptidoglycan

15. B) are metabolic analogs of PABA and block folic acid synthesis

16. C) attach to the 30S ribosomal subunit and disrupt protein synthesis

17. D) damage cell membranes

18. E) block peptidases that cross-link glycan molecules

19. Answer: attach to the 30S ribosomal subunit and disrupt protein synthesis