Question: Exemastane MOA? Give other drugs that do the same thing. What do these drugs prevent? Used to treat what?

Answer: Irreversibly bind and inhibit aromatase//

Anastrazole, Letrozole//

Prevents peripheral conversion of androgens to estrogens (testosterone to estradiol and androstenedione to estrone)//

estrogen receptor positive breast cancer

Question: Infliximab MOA? Used to treat what?

Answer: binds to and neutralizes a secreted inflammatory cytokine, TNF-α//

Psorisis

Ankylosing spondylitis

Inflammatory Bowel Disease

Rheumatoid Arthritis ((PAIR)

Question: What drug binds to and neutralizes a secreted inflammatory cytokine, TNF-α? This drug could lead to what problem?

Answer: Infliximab//

Reactivation of a latent TB infection

Question: INhibits translocation of tRNA by binding to 50S ribo subunit?

Answer: Macrolides

Question: What does prochlorperazine help with? Works where?

Answer: Anti-emetic//

at the CTZ (in the medulla at the floor of the fourth ventricle)

Question: PTU used to treat what? MOA?

Answer: Hyperthyroidism//

blocks T4 production by blocking iodine organification and also blocks peripheral conversion of T4 to the more active T3

Question: Oseltamivir//

viral neuraminidase//

release virion progeny//

48 hours//

amantadine//

uncoating//

dopaminergic//

Parkinson’s disease

Answer:

Question: Key signs of prostatic adenocarcinoma? Drug used to treat it?

Answer: Difficulty urinating and also low back pain (due to bone metastasis)//

Leuprolide and Flutamide

Question: When is only time that benefit of tamoxifen for breast cancer outweighs the risk? Why?

Answer: If the patient has had their uterus removed//

Tamoxifen is a SERM and activates estrogen receptors in the endometrium and can lead to endometrial cancer

Question: What are the 3 SERMS and what is each used to treat? Explain each.

Answer: