Sedavet
Question: Summary
Answer: Sedation, muscle relaxation, analgesia
Approval (US):
Xylazine- horses, dogs, cats, deer
Detomidine- horses
Dexmedetomidine- dogs, cats (v. effective)
Romifidine- horses (less common
Helpful with difficult to handle animals (more potent and faster than “ace”)
Question: Mechanism of Action
Answer: CNS depression by stimulating alpha2 receptors in CNS and peripherally
Reduce release of excitatory neurotransmitters (norepinephrine)
Sedation, muscle relaxation and analgesia produced
Sedation better after phenothiazines
Muscle relaxation from inhibition of polysynaptic reflexes (spinal cord)
Question: Specificity
Answer: Dexmedetomidine most alpha 2 specific (alpha1:2 is 1620:1) while xylazine is least (160:1)
Question: CV Effects
Answer:
Question: Respiratory Effects
Answer: