Sedavet

Question: Summary

Answer: Sedation, muscle relaxation, analgesia

Approval (US):

Xylazine- horses, dogs, cats, deer

Detomidine- horses

Dexmedetomidine- dogs, cats (v. effective)

Romifidine- horses (less common

Helpful with difficult to handle animals (more potent and faster than “ace”)

Question: Mechanism of Action

Answer: CNS depression by stimulating alpha2 receptors in CNS and peripherally

Reduce release of excitatory neurotransmitters (norepinephrine)

Sedation, muscle relaxation and analgesia produced

Sedation better after phenothiazines

Muscle relaxation from inhibition of polysynaptic reflexes (spinal cord)

Question: Specificity

Answer: Dexmedetomidine most alpha 2 specific (alpha1:2 is 1620:1) while xylazine is least (160:1)

Question: CV Effects

Answer:

Question: Respiratory Effects

Answer:

Donation Page

Support Our Work

Do you appreciate the value this website provides? If so, please consider donating to help keep it running. Your donation will go a long way in helping us continue to provide the same quality of content and services. Every bit helps, and your support is greatly appreciated. Thank you for your generosity.